RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
NONMMUT060091
RNA ID
RNA Type
lncrna
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qRT-PCR; Immunofluorescence; Western Blot etc.
Target
SRSF1
Pathway
NA
PubMed ID
Title
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1
Year
2021
Function
"A series of molecular assays to assess the role of the novel lncRNA NONMMUT060091, designated as pulmonary fibrosis inhibitor (PFI), which was significantly downregulated in lung fibrosis. Functionally, knockdown of endogenous PFI by smart silencer promoted proliferation, differentiation, and extracellular matrix (ECM) deposition in primary mouse lung fibroblasts (MLFs)."